Well, there was that hanky-panky between the villagers of Innsmouth and the Deep Ones.
And it’s not hard to see that the Pandoravirus is a variation on this theme to give it a scientific, rather than an esoteric explanation.
You really think so? Not only is it part of the main story, but there are tidbits of it in the random text adventures on the geoscape… May I assume you didn’t finish the game?
To paraphrase Sol Stein, readers love in fiction what they hate in real life. To quote myself from a post yesterday on a different thread: